Planta Med 1989; 55(4): 379-384
DOI: 10.1055/s-2006-962032

© Georg Thieme Verlag Stuttgart · New York

Proanthocyanidins from Krameria triandra Root

Eberhard Scholz, Horst Rimpler
  • Institut für Pharmazeutische Biologie der Universität, Schänzlestr. 1, D-7800 Freiburg/B., Federal Republic of Germany
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Publication History


Publication Date:
24 January 2007 (online)


Oligomeric proanthocyanidins were isolated from rhatany root (Krameria triandra) and characterised by acid hydrolysis, thiolytic degradation, and spectroscopic methods. They consisted of 2-14 flavanol units with mainly 2,3-cis configuration and with a propelargonidin: procyanidin ratio of 65:35. The predominant interflavan linkage was [4,8]. [4,6]-Bonds were present in the higher oligomers, presumably forming branched chain units. The astringency of the drug was mainly due to proanthocyanidins with degrees of polymerization from 5-10, and these were also the astringent compounds of rhatany tea and tincture. A pharmacological screening of the extract revealed a significant antimicrobial effect.