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Planta Med 1989; 55(3): 276-280
DOI: 10.1055/s-2006-962003
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© Georg Thieme Verlag Stuttgart · New York

New Antihepatotoxic Naphtho-pyrone Glycosides from the Seeds of Cassia tora 1

Sui-Ming Wong, Mary Moy Wong, Otto Seligmann, Hildebert Wagner
  • Institut für Pharmazeutische Biologie der Universität München, Karlstraße 29, D-8000 München 2, Federal Republic of Germany
1 Part 17 in the University of Munich series on “drugs for liver therapy”. For part 16, see Arzneim.-Forsch./Drug Res. (1988) 38, 661
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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

Two new naphtho-pyrone glycosides, 9-[(β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl)oxy]-10-hydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-1 -one (5) and 6-[(α-apiofuranosyl-(1→6)-O-β-D-glucopyrano-syl)oxy]-rubrofusarin (6), together with cassiaside (3) and rubrofusarin-6-β-gentiobioside (4) were isolated from the seeds of Cassia tora L. Their structures were elucidated on the basis of chemical and spectral data. The naphtho-γ-pyrone glycosides (3, 4, and 6) were found to have significant hepato-protective effects against galactosamine damage, which were higher than that of silybin from Silybum marianum.