HPLC Analysis of the Main Furanocoumarins from Peucedanum palustre

Heikki Vuorela; Karin Dallenbach-Tölke; Szabolcs Nyiredy; Raimo Hiltunen; Otto Sticher

doi:10.1055/s-2006-961919

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Planta Med 1989; 55(2): 181-184
DOI: 10.1055/s-2006-961919

Papers

HPLC Analysis of the Main Furanocoumarins from Peucedanum palustre

Heikki Vuorela¹ , Karin Dallenbach-Tölke² , Szabolcs Nyiredy² , Raimo Hiltunen¹ , Otto Sticher²

¹Division of Pharmacognosy, Department of Pharmacy, University of Helsinki, SF-00170 Helsinki, Finland
²Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zürich, CH-8092 Zürich, Switzerland

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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

The main furanocoumarins from the roots of Peucedanum palustre were separated with a RP-HPLC method. The mobile phase for the separation of the eight main compounds (oxypeucedanin hydrate, bergapten, oxypeucedanin, isobyakangelicin angelate, ostruthol, imperatorin, isoimperatorin, and columbianadin) was optimized with the “PRISMA” model, which is a multi-solvent optimization system. The chromatographic method can be applied for quantitative determination, as was demonstrated for different samples of P. palustre. The purity and identity of the peaks were controlled by diode-array detection and comparison with standards.