Antifertility Principle of Ruta graveolens

Y. C. Kong; C. P. Lau; K. H. Wat; K. H. Ng; P. P. H. But; K. F. Cheng; P. G. Waterman

doi:10.1055/s-2006-961917

Planta Medica, Table of Contents

Planta Med 1989; 55(2): 176-178
DOI: 10.1055/s-2006-961917

Papers

Antifertility Principle of Ruta graveolens

Y. C. Kong¹ , C. P. Lau¹ , K. H. Wat¹ , K. H. Ng¹ , P. P. H. But² , K. F. Cheng³ , P. G. Waterman⁴

¹Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
²Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
³Department of Chemistry, University of Hong Kong, Pokfulam Road, Hong Kong
⁴Phytochemistry Research Laboratories, Department of Pharmacy, University of Strathclyde, Glasgow Gl 1XW, U.K.

Abstract

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Abstract

Chloroform extracts of the root, stem and leaf of Ruta graveolens L. showed significant anti-fertility activity in rats when administered intragastrically on days 1-10 post-coitum. Fractionation of the extracts led to the isolation of chalepensin as the active component with some toxicity. Time-dosing experiments demonstrated that chalepensin acts at the early stages of pregnancy. It is not clear at this stage if the anti-fertility effect is a direct manifestation of chalepensin toxicity.

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