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Planta Med 1989; 55(1): 18-21
DOI: 10.1055/s-2006-961767
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© Georg Thieme Verlag Stuttgart · New York

Studies of Panax japonicus Fibrinolysis

Hideaki Matsuda, Kei-ichi Samukawa, Seiya Fukuda, Hidemi Shiomoto, Tong Chun-ning, Michinori Kubo
  • Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashiosaka, Osaka 577, Japan.
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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

The effects of a 70% methanol extract (PMe) obtained from the rhizomes of Panax japonicus C.A. Meyer on experimental thrombosis and fibrinolysis were investigated in vivo and in vitro. PMe showed a promotive effect on the activaction of the fibrinolytic system as determined by the euglobulin lysis time (ELT) assay but was inactive to the inhibitory effect against endotoxin-induced disseminated intravascular coagulation (DIC) in rats. PMe and its major components, chikusetsusaponin III, IV, and V, strongly promoted the action of urokinase in fibrin plate. These results suggested that PMe promotes the fibrinolysis and its effective components are chikusetsusaponin III, IV, and V.