Planta Med 1992; 58(6): 499-504
DOI: 10.1055/s-2006-961535
Papers

© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity of Gallic Acid

B. H. Kroes1 , A. J. J. van den Berg1 , H. C. Quarles van Ufford1 , H. van Dijk2 , R. P. Labadie1
  • 1Research Centre for Natural Products and Phytopharmaceuticals, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3508 TB Utrecht, The Netherlands
  • 2Section of Experimental Immunology, Laboratory of Microbiology, Medical Faculty, University of Utrecht, The Netherlands
Further Information

Publication History

12 16 1991

Publication Date:
05 January 2007 (online)

Abstract

Gallic acid was found to possess anti-inflammatory activity towards zymosan-induced acute food pad swelling in mice. In vitro studies on the mode of action of gallic acid revealed that this compound interferes with the functioning of polymorphonuclear leukocytes (PMNs). Scavenging of superoxide anions, inhibition of myeloperoxidase release and activity as well as a possible interference with the assembly of active NADPH-oxidase may account for the inhibition of inflammatory process by gallic acid. Structure-activity relationship analysis showed that the o-dihydroxy group of gallic acid is important for the inhibitory activity in vitro.