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Planta Med 1992; 58(4): 338-341
DOI: 10.1055/s-2006-961480
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© Georg Thieme Verlag Stuttgart · New York

Anethofuran, Carvone, and Limonene: Potential Cancer Chemoprotective Agents from Dill Weed Oil and Caraway Oil

Guo-qiang Zheng, Patrick M. Kenney, Luke K.T. Lam
  • LKT Laboratories Inc., 2010 East Hennepin Avenue, Minneapolis, Minnesota 55413, U.S.A.
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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Bioassay-directed fractionation of dill weed oil and caraway oil, respectively, from the plants Anethum graveolens L. and Carum carvi L. (Umbelliferae) has led to the isolation of three monoterpenes, anethofuran (1), carvone (2), and limonene (3). Their structures were determined on the basis of spectral analysis. These compounds induced the detoxifying enzyme glutathione S-transferase in several mouse target tissues. The α,β-unsaturated ketone system in carvone appeared to be critical for the high enzyme-inducing activity.

Key words

Anethofuran - carvone - limonene - inducing effect - glutathione S-transferase - Anethum graveolens - Cavum carvi