Planta Medica, Table of Contents Planta Med 1992; 58(4): 334-337DOI: 10.1055/s-2006-961479 Papers © Georg Thieme Verlag Stuttgart · New YorkThe Molluscicidal Activity of Coumarins from Ethulia conyzoides and of DicumarolM. M. Kady1 , 5 , Leon Brimer1 , 4 , P. Furu1 , Else Lemmich1 , 2 , H. Marie Nielsen2 , Susanne T. Thiilborg1 , 2 , Ole Thastrup3 , S. Brøgger Christensen2 1Danish Bilharziasis Laboratory, DK-2920 Charlottenlund, Denmark 2Department of Organic Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark 3Symbion, Haraldsgade, DK-2100 Copenhagen Ø, Denmark 4Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Bülowsvej 13, DK-1870 Frederiksberg, Denmark 5Pesticide Division, Faculty of Agriculture, Mansoura University, Mansoura, Egypt Recommend Article Abstract PDF Download Buy Article Abstract The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity. Key words Ethulia conyzoides - molluscicidal activity - ovicidal activity - cercaricidal activity - ethuliacoumarin A - isoethuliacoumarin A - dicumarol - warfarin PDF (322 kb)
