Mitogenic and Complement Activating Activities of the Herbal Components of Juzen-Taiho-To1

Haruki Yamada; Hiroaki Kiyohara; Norito Takemoto; Ji-Fu Zhao; Hideki Kawamura; Yasuhiro Komatsu; Jong-Chol Cyong; Masaki Aburada; Eikichi Hosoya

doi:10.1055/s-2006-961421

Planta Med 1992; 58(2): 166-170
DOI: 10.1055/s-2006-961421

Papers

Mitogenic and Complement Activating Activities of the Herbal Components of Juzen-Taiho-To¹

Haruki Yamada² , Hiroaki Kiyohara² , Norito Takemoto³ , Ji-Fu Zhao² ^, ⁴ , Hideki Kawamura³ , Yasuhiro Komatsu³ , Jong-Chol Cyong² , Masaki Aburada³ , Eikichi Hosoya³

²Oriental Medicine Research Center of the Kitasato Institute, Minato-ku, Tokyo 108, Japan
³Tsumura Research Institute for Pharmacology, Ibaraki 300-11, Japan
⁴Shenyang Pharmaceutical College, Shenyang, China

1 Part III in the series “Studies on Immunologically Active Substances from Kampo Medicine, Juzen-Taiho-To”. For part I and II, see Refs. (5,6)

Abstract

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Abstract

The Kampo (Japanese herbal) medicine “Juzen-Taiho-To” (TJ-48), which was prepared by decocting a concoction (formula), contains ten kinds of herbs and has several immunostimulating activities. In order to determine the contribution of each herbal component, the complement-activating and mitogenic activities of the hot water extract as well as the polysaccharide fraction from each herb were tested. Hot water extracts of Glycyrrhizae radix, Astragali radix, and Atractylodis lanceae rhizoma showed significant mitogenic activity whereas that of Cinnamomi cortex showed potent complement-activating activity. However, the exclusion of any single component herb whether active or not on its own did not result in a loss or an increase of the overall activity of TJ-48. The polysaccharide fraction from Glycyrrhizae radix showed the most potent of both activities among the same fractions from the other nine herbs, and reduced both activities after periodate oxidation, thus indicating that the carbohydrate moiety may contribute to both activities.

Key words

Kampo (Japanese herbal) medicine - Juzen-Taiho-To - complement-activating activity - mitogenic activity - immunostimulating activity

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