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DOI: 10.1055/s-2006-961385
© Georg Thieme Verlag Stuttgart · New York
Benzophenanthridine Alkaloids Isolated from Eschscholtzia californica Cell Suspension Cultures Interact with Vasopressin (V1) Receptors
Publication History
1991
Publication Date:
04 January 2007 (online)

Abstract
Chelerythrine and sanguinarine, two benzophenanthridine alkaloids, have been isolated from a crude methanolic extract of Eschscholtzia californica cell suspension cultures by successive fractionations. These two molecules exhibited affinity for rat liver vasopressin V1 receptors and are competitive inhibitors of [3 H]-vasopressin binding within the micromolar range (Ki). Chelerythrine and sanguinarine represent two of the first non-peptidic structures providing original chemical leads for the design of synthetic vasopressin compounds.
Key words
Eschscholtzia californica - Papaveraceae - benzophenanthridine alkaloids - vasopressin V1-receptors