Planta Medica, Inhaltsverzeichnis Planta Med 1992; 58(1): 31-34DOI: 10.1055/s-2006-961384 Paper © Georg Thieme Verlag Stuttgart · New YorkTransformation of Progesterone by Traemetes hispida J. S. Dahiya1 , 2 1Department of Plant Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada 2ABI Biotechnology Incorporated, 40 Scurfield Blvd., Winnipeg, Manitoba R3Y 1G4, Canada Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) Abstract Traemetes hispida was found to convert progesterone into a mixture of various products. Five products were isolated in sufficient amounts by HPLC analysis for structural identification and characterization. Three products were found to have two hydroxy moieties on axial and equatorial positions at 7β,15β, 6β, 11α, and 11α, 15β sites. The other two products had an extra 17α-hydroxy on the above dihydroxy derivatives to give trihydroxyprogesterone. The hydroxylating steps caused by this strain were greatly influenced by the 17β side chain, especially by the C-20 moiety in the steroidal skeleton. Key words Traemetes hispida - fungus - progesterone - transformation - 1H-NMR - 13C-NMR - mass spectral analysis PDF (292 kb)
