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Planta Med 1990; 56(5): 446-450
DOI: 10.1055/s-2006-961008
Paper

© Georg Thieme Verlag Stuttgart · New York

Strobilurin D and Strobilurin F: Two New Cytostatic and Antifungal (E)-β-Methoxyacrylate Antibiotics from Cyphellopsis anomala

Wolfgang Weber1 , Timm Anke1 , Monika Bross2 , Wolfgang Steglich2
  • 1Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul-Ehrlich-Str.23, D-6750 Kaiserslautern, Federal Republic of Germany
  • 2Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str.1, D-5300 Bonn 1, Federal Republic of Germany
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Strobilurin D and Strobilurin F, two new cytostatic and antifungal antibiotics of the (E)-β-methoxyacrylate class, have been isolated from mycelial cultures of the basidiomycete Cyphellopsis anomala (Pers. ex Fr.) Sing. The structures were elucidated by spectroscopic methods. The antibiotics inhibit the growth of human and animal cells and a wide variety of fungi. Like strobilurins A and B, the new metabolites are potent inhibitors of respiration.

Key words

Strobilurin D and F - antifungal activity - cytostatic activity - Cyphellopsis anomala.