The Cytotoxic Principles of Pseudolarix kaempferi: Pseudolaric Acid-A and -B and Related Derivatives1

De-Ji Pan; Zhu-Lian Li; Chang-Qi Hu; Ke Chen; Jer-Jang Chang; Kuo-Hsiung Lee

doi:10.1055/s-2006-960989

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Planta Med 1990; 56(4): 383-385
DOI: 10.1055/s-2006-960989

Papers

The Cytotoxic Principles of Pseudolarix kaempferi: Pseudolaric Acid-A and -B and Related Derivatives¹

De-Ji Pan¹ , Zhu-Lian Li² , Chang-Qi Hu¹ , Ke Chen² , Jer-Jang Chang³ , Kuo-Hsiung Lee¹

¹Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.
²School of Pharmacy, Shanghai Medical University, Shanghai 200032, People's Republic of China
³Division of Laboratory Animal Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.

1 Antitumor Agents: 109. For paper 108 in this series, see Wu, Y.C., Yamagishi, T., Lee, K. H. (1990) Kaohsiung J. Med. Sci., in press

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Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.

Key words

Pseudolarix kaempferi - pseudolaric acid-A and -B - diterpene acids - cytotoxic principles