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The Cytotoxic Principles of Pseudolarix kaempferi: Pseudolaric Acid-A and -B and Related Derivatives11 Antitumor Agents: 109. For paper 108 in this series, see Wu, Y.C., Yamagishi, T., Lee, K. H. (1990) Kaohsiung J. Med. Sci., in press
05 January 2007 (online)
Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.
Pseudolarix kaempferi - pseudolaric acid-A and -B - diterpene acids - cytotoxic principles