Cytotoxic and Antitumor Constituents in Pericarps of Mallotus japonicus

Munehisa Arisawa; Akio Fujita; Naokata Morita; Saburo Koshimura

doi:10.1055/s-2006-960987

Planta Medica, Inhaltsverzeichnis

Planta Med 1990; 56(4): 377-379
DOI: 10.1055/s-2006-960987

Papers

Cytotoxic and Antitumor Constituents in Pericarps of Mallotus japonicus

Munehisa Arisawa¹ , Akio Fujita¹ , Naokata Morita¹ , Saburo Koshimura²

¹Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
²Department of Serology, Kanazawa Medical University, 1-1 Daigaku Uchinada-machi Kahokugun, Ishikawa 920-02, Japan

Abstract

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Abstract

A variety of phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus were assessed for growth inhibiting activity against human larynx (HEp-2) and lung (PC-13) carcinoma cells as well as mouse B16 melanoma, leukemia P388, and L5178Y cells. Most of these derivatives were proved to be significantly cytotoxic in culture. One of them, 3-(3,3-di-methylallyl)-5-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzyl)-phloracetophenone (1) showed an excellent cytotoxicity against all target tumor cells and a marked prolongation of life-span in mice bearing L5178Y leukemia.

Key words

Mallotus japonicus - cytotoxicity - antitumor constituent - combined use - multiple effect

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