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Planta Med 1990; 56(4): 368-370
DOI: 10.1055/s-2006-960984
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© Georg Thieme Verlag Stuttgart · New York

Antimalarial Activity of Tanzanian Medicinal Plants1

H. Weenen2 , M. H. H. Nkunya2 , D. H. Bray3 , L. B. Mwasumbi4 , L. S. Kinabo2 , V. A. E. B. Kilimali5
  • 2Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania
  • 3Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.
  • 4Department of Botany, University of Dar es Salaam, P.O. Box 35060, Dar es Salaam, Tanzania
  • 5National Institute for Medical Research, Amani Research Centre, P.O. Box 4, Amani, Tanzania
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1989

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

Tanzanian medicinal plants were extracted and tested for in vitro antimalarial activity, using the multidrug resistant K1 strain of Plasmodium falciparum. Of 49 plants investigated, extracts of three plants were found to have an IC50 between 5-10 µg/ml, extracts of 18 other plants showed an IC50 between 10 and 50 µg/ml, all others were less active. The three most active extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Hoslundia opposita Vahl. (Labiatae), and the rootbark of Lantana camara L. (Verbenaceae).

Key words

Tanzanian - medicinal plants - antimalarial activity - Plasmodium falciparum - Cyperus rotundus - Hoslundia opposita - Lantana camara