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Planta Med 1990; 56(2): 187-189
DOI: 10.1055/s-2006-960922
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© Georg Thieme Verlag Stuttgart · New York

A Novel Antibacterial Diterpene from Premna schimperi

Solomon Habtemariam1 , Alexander I. Gray2 , Gavin W. Halbert3 , Peter G. Waterman2
  • 1Department of Chemistry, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
  • 2Phytochemistty Research Laboratories, Department of Pharmacy, University of Strathclyde, Glasgow G1 1 XW, Scotland, U.K.
  • 3Division of Pharmaceutics, Department of Pharmacy, University of Strathclyde, Glasgow G1 1 XW, Scotland, U.K.
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

A novel diterpene, (5R,8R,9S,10R)-12-oxo-ent-3,13(16)-clerodien-15-oic acid, has been obtained from the leaves of Premna schimperi (Verbenaceae) using an anti-microbial bioassay-guided isolation procedure. The diterpene was identified on the basis of spectroscopic data and is active against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis in the concentration range 20-25 µg ml-1.

Key words

Premna schimperi - Verbenaceae - novel clerodane diterpene - antibacterial activity