Tert-Butyl Hydroperoxide-Induced Injury In Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs

Michel Joyeux; Alain Rolland; Jacques Fleurentin; François Mortier; Pierre Dorfman

doi:10.1055/s-2006-960918

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Planta Med 1990; 56(2): 171-174
DOI: 10.1055/s-2006-960918

Papers

Tert-Butyl Hydroperoxide-Induced Injury In Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs

Michel Joyeux¹ ^, ² , Alain Rolland¹ , Jacques Fleurentin¹ , François Mortier³ , Pierre Dorfman²

¹Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Université de Metz, 1, rue des Récollets, F-57000 Metz, France
²Laboratoire DOLISOS, 63, rue Baubourg, F-75003 Paris, France
³Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Nancy, 5, rue Albert Lebrun, F-54000 Nancy, France

Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Tert-butyl hydroperoxide induces in freshly isolated rat hepatocytes malonaldehyde formation and lacticodehydrogenase and aspartate aminotransferase leakage. This model, when adapted to crude extracts, permits the demonstration of both anti-lipoperoxidant and antihepatotoxic activity of reference products like quercetin and silymarin and plant extracts like Rosmarinus officinalis and Eschscholzia californica.

Key words

Hepatocytes - tert-butyl hydroperoxide - Rosmarinus officinalis