Planta Med 1990; 56(1): 66-69
DOI: 10.1055/s-2006-960886

© Georg Thieme Verlag Stuttgart · New York

In Vitro Activity of Protoanemonin, an Antifungal Agent

M. Luisa Martín1 , Luis San Román1 , Angel Domínguez2
  • 1Departamento de Fisiologia y Farmacología, Universidad de Salamanca, 37071 Salamanca, Spain
  • 2Departamento de Microbiología, Genética, Medicina Preventiva y Salud Pública, Universidad de Salamanca, 37071 Salamanca, Spain
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Publication History


Publication Date:
05 January 2007 (online)


Protoanemonin, the lactone of γ-hydroxyvinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 µg/ml and RNA inhibition seems to be the first target of the drug. The LD50 of protoanemonin in male Swiss albino mice was 190 mg/kg.