© Georg Thieme Verlag Stuttgart · New York
In Vitro Activity of Protoanemonin, an Antifungal Agent
05 January 2007 (online)
Protoanemonin, the lactone of γ-hydroxyvinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 µg/ml and RNA inhibition seems to be the first target of the drug. The LD50 of protoanemonin in male Swiss albino mice was 190 mg/kg.
Pulsatilla alpina - Ranunculaceae - protoanemonin - anti Fungal