Planta Med 1990; 56(1): 48-52
DOI: 10.1055/s-2006-960882

© Georg Thieme Verlag Stuttgart · New York

A Novel N 6-Substituted Adenosine Isolated from Mi Huan Jun (Armillaria mellea) as a Cerebral-Protecting Compound

Naoharu Watanabe1 , Tadashi Obuchi1 , Masaharu Tamai1 , Hiroaki Araki1 , Sadafumi Omura1 , Yang Jun-Shan2 , Yu De-Quan2 , Liang Xiao-Tian2 , Huan Jun-Hua2
  • 1Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Omiya, Saitama 330, Japan
  • 2Institute of Materia Medica, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, People's Republic of China
Further Information

Publication History


Publication Date:
05 January 2007 (online)


Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridylmethylamino)-9-β-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra.