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Anti-Inflammatory Activity of Ginsenoside Ro11 Pharmacological Study on Panax ginseng C. A. Meyer; part XI. For part X, see Kubo, M., Samukawa, K., Matsuda, H. (1989) J. Med. Pharm. Soc. Wakan-Yaku 6, 45.
05 January 2007 (online)
Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of inflammation. Ginsenoside Ro (10,50, and 200 mg/kg, p. o.) inhibited an increase in vascular permeability in mice induced by acetic acid and reduced an acute paw edema in rats induced by compound 48/80 or carrageenin. Ginsenoside Ro did not suppress a developing adjuvant-induced edema in arthritic rats. However, ginsenoside Ro was found to be effective in hypercoagulable state, increase of connective tissue in the artery and calcium effluence from the bone in adjuvant-induced arthritic rats
Panax ginseng - ginsenoside Ro - inflammation - adjuvant-induced arthritis - connective tissue - clacium effluence