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Planta Med 1999; 65(8): 754-756
DOI: 10.1055/s-2006-960858
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© Georg Thieme Verlag Stuttgart · New York

Antimalarials from Stephania venosa, Prismatomeris sessiliflora, Diospyros montana and Murraya siamensis 1

Kittisak Likhitwitayawuid2 , Sukanya Dej-adisai2 , 4 , Vichien Jongbunprasert2 , Jerapan Krungkrai3
  • 2Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
  • 3Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  • 4Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla, Thailand
1 Presented, in part, at the 46th Annual Congress Society for Medicinal Plant Research, August, 31 - September, 4, 1998, University of Vienna, Austria
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1999

1999

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

Fourteen compounds isolated from Stephania venosa, Prismatomeris sessiliflora, Diospyros montana and Murraya siamensis were tested for their antimalarial potential. The 6a,7-dehydroaporphine alkaloids dehydrostephanine and dehydrocrebanine showed potent activity with IC50values of 40 and 70 ng/ml, respectively. The 13C-NMR data of rubiadin, rubiadin-1-methyl ether, diospyrin and 5-hydroxy-4-methoxy-2-naphthaldehyde were extensively studied.