Planta Med 1999; 65(7): 654-655
DOI: 10.1055/s-2006-960839

© Georg Thieme Verlag Stuttgart · New York

Inhibition of Mast Cell Degranulation by Tanshinones from the Roots of Salvia miltiorrhiza

Shi Yong Ryu1 , Min-Ho Oak2 , Kyeong-Man Kim2
  • 1Korea Research Institute of Chemical Technology, Yusung, Taejeon, Korea
  • 2Pharmacology Laboratory, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea
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Publication History



Publication Date:
04 January 2007 (online)


The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release of β-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the IC50 values were calculated as 16 and 36 µM, respectively.