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Planta Med 1999; 65(5): 455-457
DOI: 10.1055/s-2006-960811
Letter

© Georg Thieme Verlag Stuttgart · New York

A New Phenolic Fatty Acid Ester with Lipoxygenase Inhibitory Activity from Jacaranda filicifolia

Rasadah Mat Ali1 , Peter J. Houghton2
  • 1Forest Research Institute Malaysia, Kepong, Kuala Lumpur Malaysia
  • 2Department of Pharmacy, King's College London, London, U.K.
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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

The dichloromethane extract of the stem of Jacaranda filicifolia Don. showed inhibitory activity in vitro against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid, β-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.