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Planta Med 1999; 65(5): 444-446
DOI: 10.1055/s-2006-960806
Letter

© Georg Thieme Verlag Stuttgart · New York

Evaluation of the Antimicrobial Potency of Tannins and Related Compounds Using the Microdilution Broth Method

Herbert Kolodziej1 , Oliver Kayser1 , Klaus Peter Latté1 , Daneel Ferreira2
  • 1Institut für Pharmazie II, Freie Universität Berlin, Berlin, Germany
  • 2Department of Chemistry, University of the Orange Free State, Bloemfontein, South Africa
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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

The antimicrobial activity of a total of 27 tannins and related compounds was evaluated against 8 microorganisms, including 2 Gram-positive (Bacillus subtilis, Staphylococcus aureus), 4 Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis), and 2 yeasts (Candida albicans, Cryptococcus neoformans). The compounds tested were generally found to possess only weak to moderate antibacterial, but fairly high anticryptococcal activities. Attention is given to structure-activity relationships with emphasis on simple galloyl esters, hydrolyzable tannins and proanthocyanidins among this class of secondary products.