Planta Med 1999; 65(4): 378-381
DOI: 10.1055/s-2006-960794
Letters

© Georg Thieme Verlag Stuttgart · New York

In vitro Antimalarial Activity and Cytotoxicity of Cochlospermum tinctorium and C planchonii Leaf Extracts and Essential Oils

Françoie Benoit-Vical1 , Alexis Valentin1 , Michèle Mallíe1 , Jean-Marie Bastide1 , Jean-Marie Bessière2
  • 1Laboratoire d'Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, Montpellier, France
  • 2Ecole Nationale Supérieure de Chimie, Montpellier, France
Weitere Informationen

Publikationsverlauf

1998

1998

Publikationsdatum:
04. Januar 2007 (online)

Abstract

The antimalarial and toxicological properties of Cochlospermum tinctorium and C. planchonii extracts and essential oils prepared from their leaves were studied. The oil components were extracted by hydrodistillation of the plant leaves and characterized by gas chromatography and mass spectrometry. Crude extracts and oils were tested for in vitro antimalarial activity on Plasmodium falciparum. The IC50 were evaluated after 24 and 72 h contact between the oils and the parasite culture, and ranged from 22 to 500 µg/ml. C. planchonii leaf oil yielded the best antimalarial effect (IC50: 22 - 35 µg/ml), while the most potent effect from crude leaf extracts was induced by C. tinctorium. The cytotoxicity of the leaf crude extracts and oils was assessed on the K562 cell line and showed IC50 values ranging between 33 and 2000 µg/ml.