A New Rosmarinic Acid Derivative from Isodon oresbius

H. Huang; Q.-R. Chao; R. X. Tan; H.-D. Sun; D.-C. Wang; J. Ma; S.-X. Zhao

doi:10.1055/s-2006-960451

Planta Medica, Table of Contents

Planta Med 1999; 65(1): 92-93
DOI: 10.1055/s-2006-960451

Letter

A New Rosmarinic Acid Derivative from Isodon oresbius

H. Huang¹ , Q.-R. Chao² , R. X. Tan¹ , H.-D. Sun³ , D.-C. Wang⁴ , J. Ma⁵ , S.-X. Zhao⁵

¹Department of Biological Science & Technology, Nanjing University, Nanjing, P.R. China (Present address: Institute of Organic Chemistry, Academia Sinica, Shanghai, China)
²State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, P.R. China (Present address: Institute of Organic Chemistry, Academia Sinica, Shanghai, China)
³Kunming Institute of Botany, Academia Sinica, Kunming, P.R. China
⁴Jiangsu Institute of Materia Medica, Jiangsu Province & Academia Sinica, Nanjing, P. R. China
⁵Department of Phytochemistry, China Pharmaceutical University, Nanjing, P. R. China

Abstract

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Abstract

Phytochemical reinvestigation of Isodon oresbius afforded, in addition to oleanolic acid, ursolic acid, sodoponin, astragalin, and quercetin-3-O-glucoside, three known (oresbiusin A, rosmarinic acid and methyl rosmarinate) and a new rosmarinic acid derivative as well as an ent-kaurene diterpenoid, neo-angustifolin, characterized as a separated component for the first time. By a combination of 1D- and 2D-NMR techniques the structure of the new compound was established as butyl rosmarinate. The in vitro antifungal assay showed that neoangustifolin was active against Candida albicans with the MIC being 50 µg/ml.

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