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Planta Med 1999; 65(1): 92-93
DOI: 10.1055/s-2006-960451
Letter

© Georg Thieme Verlag Stuttgart · New York

A New Rosmarinic Acid Derivative from Isodon oresbius

H. Huang1 , Q.-R. Chao2 , R. X. Tan1 , H.-D. Sun3 , D.-C. Wang4 , J. Ma5 , S.-X. Zhao5
  • 1Department of Biological Science & Technology, Nanjing University, Nanjing, P.R. China (Present address: Institute of Organic Chemistry, Academia Sinica, Shanghai, China)
  • 2State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, P.R. China (Present address: Institute of Organic Chemistry, Academia Sinica, Shanghai, China)
  • 3Kunming Institute of Botany, Academia Sinica, Kunming, P.R. China
  • 4Jiangsu Institute of Materia Medica, Jiangsu Province & Academia Sinica, Nanjing, P. R. China
  • 5Department of Phytochemistry, China Pharmaceutical University, Nanjing, P. R. China
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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

Phytochemical reinvestigation of Isodon oresbius afforded, in addition to oleanolic acid, ursolic acid, sodoponin, astragalin, and quercetin-3-O-glucoside, three known (oresbiusin A, rosmarinic acid and methyl rosmarinate) and a new rosmarinic acid derivative as well as an ent-kaurene diterpenoid, neo-angustifolin, characterized as a separated component for the first time. By a combination of 1D- and 2D-NMR techniques the structure of the new compound was established as butyl rosmarinate. The in vitro antifungal assay showed that neoangustifolin was active against Candida albicans with the MIC being 50 µg/ml.