Compounds Inhibiting Prostaglandin Synthesis Isolated from Ipomoea pes-caprae

U. Pongprayoon; P. Baeckström; U. Jacobsson; M. Lindström; L. Bohlin

doi:10.1055/s-2006-960196

Planta Medica, Table of Contents

Planta Med 1991; 57(6): 515-518
DOI: 10.1055/s-2006-960196

Papers

Compounds Inhibiting Prostaglandin Synthesis Isolated from Ipomoea pes-caprae

U. Pongprayoon¹ ^, ³ , P. Baeckström² , U. Jacobsson² , M. Lindström² , L. Bohlin¹

¹Department of Pharmacognosy, Biomedical Center, Uppsala University, Box 579, S-75123 Uppsala, Sweden
²Department of Organic Chemistry, Royal Institute of Technology, S-10044 Stockholm, Sweden
³Thailand Institute of Scientific and Technological Research, Bangkok 10900, Thailand

Abstract

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Abstract

The crude extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br. showed an inhibitory effect on prostaglandin synthesis in vitro. Bioassay-guided separation of the extract led to the isolation of four active compounds: 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), (-)-mellein (2), eugenol (3), and 4-vinylguaiacol (4). Among the isolated compounds, 3 and 4 were the most active with IC₅₀ values of 9.2 and 18 µM, respectively. For 1 and 2 the IC₅₀ values were 230 and 340 µM, respectively. The influence of 1, 2, 3, and 4 on the formation of prostaglandins may partly explain a previously observed anti-inflammatory effect of the extract IPA.

Key words

Ipomoea pes-caprae (L.) R. Br. - 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone - (-)-mellein - eugenol - 4-vinylguaiacol - prostaglandin synthesis

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