Download PDF
Planta Med 1991; 57(5): 437-439
DOI: 10.1055/s-2006-960144
Papers

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Activity of Amaryllidaceae Alkaloids from Crinum augustum and Crinum bulbispermum

M. A. Abd El Hafiz1 , M. A. Ramadan1 , M. L. Jung2 , J. P. Beck2 , R. Anton3
  • 1Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt
  • 2Laboratoire de Recherches en Immunologie, Université Louis Pasteur, F-67091 Strasbourg, France
  • 3Laboratoire de Pharmacognosie, Faculté de Pharmacie, B.P. 24, F-67401 Illkirch Cédex, France
Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

Also available at
 PDF Download  Permissions and Reprints

Abstract

The cytotoxic activity of five minor Amaryllidaceae alkaloids and one flavan isolated from Crinum augustum Rox and Crinum bulbispermum Milne were tested on human leukemic Molt 4 cells. Whereas the crinine-type alkaloids (6α-hydroxycrinine, powelline) and the new type augustamine did not even inhibit the growth of Molt 4 cells, the lycorine-type alkaloid (pratorinine) and the crinine-type alkaloid (6α-hydroxybuphanisine) showed a moderate cytotoxic activity and the flavan (4′-hydroxy-7-methoxyflavan) showed an important cytotoxic effect.

Key words

Crinum augustum - Crinum bulbispermum - Amaryllidaceae alkaloids - cytotoxic effects - flavans