Bioactive Principles from the Roots of Lindera megaphylla

C. C. Chen; Y. L. Huang; J. C. Ou; M. J. Su; S. M. Yu; C. M. Teng

doi:10.1055/s-2006-960135

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Planta Med 1991; 57(5): 406-408
DOI: 10.1055/s-2006-960135

Papers

Bioactive Principles from the Roots of Lindera megaphylla

C. C. Chen¹ , Y. L. Huang¹ , J. C. Ou¹ , M. J. Su² , S. M. Yu² , C. M. Teng²

¹National Research Institute of Chinese Medicine, 2 Lane 391, Pei-I Rd. Sec. 2, Hsintein, Taipei Hsien, Taiwan 23177, Republic of China
²Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

d-Dicentrine was isolated from the root of Lindera megaphylla. It inhibited the aggregation of washed rabbit platelets induced by ADP, collagen, arachidonic acid, and PAF. It also inhibited the high potassium- and norepinephrine-induced contraction of rat thoracic aorta. In rat ventricular cells treated with 3 µM d-dicentrine, the action potential duration (ADP₅₀) was prolonged from 59.9 ± 11.3 msec to 201 ± 28.7 msec.

Key words

Lindera megaphylla - d-dicentrine - anti-platelet aggregation - vasorelaxant - antiarrhythmic activity

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