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Planta Med 1991; 57(4): 325-327
DOI: 10.1055/s-2006-960108
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© Georg Thieme Verlag Stuttgart · New York

Influence of Tridax procumbens on Lysyl Oxidase Activity and Wound Healing

S. L. Udupa1 , A. L. Udupa2 , D. R. Kulkarni2
  • 1Department of Biochemistry, Kasturba Medical College, Manipal 576 119, Karnataka, India
  • 2Department of Pharmacology, Kasturba Medical College, Manipal 576 119, Karnatake, India
Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

The effects of an indigenous drug, Tridax procumbens L. (Compositae), on developing granulation tissue in rats were studied. Subcutaneously harvested granuloma tissue formed on dead space wound was removed at 4 day intervals up to 32 days of wounding. Lysyl oxidase activity, protein content, specific activity, and breaking strength were all increased in drug-treated animals as compared to controls. A fall in the lysyl oxidase activity was observed in drug-treated animals after day 8. The drug may be having a dual role: one a stimulatory (direct) effect in the initial phase of wound healing and the other a depressant (indirect) effect in the later stage.

Key words

Tridax procumbens - granulation tissue - lysyl oxidase activity - wound healing - Compositae