Planta Med 1991; 57(3): 225-231
DOI: 10.1055/s-2006-960079

© Georg Thieme Verlag Stuttgart · New York

Analgesic, Antipyretic and Anti-Inflammatory Properties of Euphorbia hirta

Marie-Claire Lanhers1 , 4 , Jacques Fleurentin1 , 4 , Pierre Dorfman3 , François Mortier2 , 4 , Jean-Marie Pelt1 , 4
  • 1Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Université de Metz, 1 rue des Récollets, F-57000 Metz, France
  • 2Laboratoire de Pharmacognosie, Université de Nancy, 5 rue Albert Lebrun, F-5400 Nancy, France
  • 3Laboratoires DOLISOS, 71 rue Beaubourg, F-75003 Paris, France
  • 4Société Française d'Ethnopharmacologie, Cloître des Récollets, F-57000 Metz, France
Further Information

Publication History


Publication Date:
05 January 2007 (online)


Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedative effect, associated with anxiolytic effects. This study leads us to the conclusion that this plant extract exerts central analgesic properties. Such a dose-dependent action was obtained against chemical (writhing test) and thermic (hot plate test) stimuli, respectively, from the doses of 20 and 25 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. An antipyretic activity was obtained at the sedative doses of 100 and 400 mg/kg, on the yeast-induced hyperthermia.

Finally, significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process (carrageenan-induced edema test in rats) from the dose of 100 mg/kg. On the other hand, plant extract remained inactive on chronic processes such as Freund's adjuvant-induced rheumatoid arthritis, after a chronic treatment during fourteen days at the daily dose of 200 or 400 mg/kg; however, if inefficacy was observed on rat backpaws edema and on loss of weight, the aqueous extract reduced the inflammatory hyperalgia.