Planta Med 1991; 57(3): 208-211
DOI: 10.1055/s-2006-960075

© Georg Thieme Verlag Stuttgart · New York

Improvement of Hyperglycemia and Hyperlipemia in Streptozotocin-Diabetic Rats by a Methanolic Extract of Prunus davidiana Stems and Its Main Component, Prunin

Jae Sue Choi1 , Takako Yokozawa3 , Hikokichi Oura3
  • 1Department of Nutrition and Food Sciences, National Fisheries University of Pusan, Pusan 608-023, Korea
  • 3Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan
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Publication History


Publication Date:
05 January 2007 (online)


Blood glucose and total lipid levels in rats with streptozotocin-induced diabetes were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. stems and its main component, prunin (= naringenin 7-O-β-D-glucoside). From the data obtained it was concluded that intraperitoneal administration of the methanolic extract and prunin produced a significant hypoglycemic effect. Total blood lipids were also decreased by these substances. Thus, it is suggested that this methanolic extract contains one or more hypoglycemic principles including the main flavanone glycoside, prunin, which can significantly reduce the levels of blood glucose and total lipids in streptozotocin-diabetic rats.