Planta Med 1991; 57(2): 132-136
DOI: 10.1055/s-2006-960049

© Georg Thieme Verlag Stuttgart · New York

Chemical Properties and Anti-Complementary Activities of Heteroglycans from the Leaves of Panax ginseng

Qi-Pin Gao1 , 2 , Hiroaki Kiyohara1 , Jong-Chol Cyong1 , Haruki Yamada1
  • 1Oriental Medicine Research Center of the Kitasato Institute, 5-9-1, Shirokane, Minato-ku, Tokyo 108, Japan
  • 2Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Chang Chun, Jilin Province, China
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Publication History


Publication Date:
05 January 2007 (online)


Four anti-complementary neutral (GL-NIa and GL-NIb) and acidic (GL-AIa and GL-AIb) polysaccharides were purified from the leaves of Panax ginseng C. A. Meyer. Only GL-NIa and GL-AIa exhibited potent anti-complementary activities at low concentrations probably through the alternative complement pathway. Glycosyl linkage analysis demonstrated that GL-NIa mainly consisted of arabinogalactan moieties, whereas GL-NIb contained large amounts of (1→4)-linked glucosyl residues. β-Elimination indicated that GL-AIa and GL-AIb were pectic polysaccharides consisting of a rhamnogalacturonan core with neutral side chains. GL-AIa reacted strongly with β-glucosyl-Yariv antigen, GL-NIa reacted weakly, whereas GL-NIb and GL-AIb showed no reaction with the antigen.