Planta Med 1991; 57(2): 129-131
DOI: 10.1055/s-2006-960048

© Georg Thieme Verlag Stuttgart · New York

4-Hydroxy-2-cyclopentenone: An Anti-Pseudomonas and Cytotoxic Component from Passiflora tetrandra 1

N. B. Perry2 , G. D. Albertson3 , J. W. Blunt2 , A. L. J. Cole3 , M. H. G. Munro2 , J. R. L. Walker3
  • 2Department of Chemistry, University of Canterbury, Christchurch, New Zealand
  • 3Department of Plant and Microbial Sciences, University of Canterbury, Christchurch, New Zealand
1 Antibiotic Compounds from New Zealand Plants; Part IV.
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Publication History


Publication Date:
05 January 2007 (online)


4-Hydroxy-2-cyclopentenone is responsible for the anti-bacterial activity of an extract of leaves from Passiflora tetrandra with minimum inhibitory doses (MID) of ca. 10 µg/disk against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. 4-Hydroxy-2-cyclopentenone is also cytotoxic to P388 murine leukemia cells (IC50 of < 1 µg/ml).