Planta Med 1991; 57(2): 125-128
DOI: 10.1055/s-2006-960047

© Georg Thieme Verlag Stuttgart · New York

Inhibition of Mutagenesis and Transformation by Root Extracts of Panax ginseng in vitro

Y. H. Rhee1 , J. H. Ahn2 , J. Choe3 , K. W. Kang3 , C. Joe3
  • 1Department of Microbiology, Chung Nam National University, Taejon 305-764, Korea
  • 2Department of Agriculture, University of Queensland, St. Lucia, QLD 4067 Brisbane, Australia
  • 3Department of Biological Science and Engineering, Korea Advanced Institute of Science and Technology, Taejon 305-701, Korea
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Publication History


Publication Date:
05 January 2007 (online)


The root extract of Panax ginseng was investigated for its inhibitory effects on DNA synthesis, mutagenicity, and cellular transformation using V79 and NIH 3T3 cells. DNA synthesis measured by the [3 H]-thymidine incorporation into V79 Chinese hamster lung cells was significantly decreased by the addition of ginseng extract (0-1 µg/ml) to the medium. However, ginseng extract was found to increase the rate of DNA excision repair synthesis in V79 cells in response to treatment with UV radiation or methyl methanesulfonate. The extract also showed decreased mutation frequency when mutagenicity was examined using V79 cells at the hypoxanthine-guanine phosphoribosyl transferase locus as resistance to 6-thioguanine after exposure to methyl methanesulfonate. We also found that the components of ginseng extract continue to exert an inhibitory effect on the transformation of NIH 3T3 cells initiated by 3-methylchloanthrene, methyl methanesulfonate, and 1-methyl-3-nitro-1-nitrosoguanidine.