Planta Med 1991; 57(2): 110-115
DOI: 10.1055/s-2006-960043

© Georg Thieme Verlag Stuttgart · New York

Hepatoprotective and Anti-Inflammatory Effects of a Traditional Medicinal Plant of Chile, Peumus boldus

Marie Claire Lanhers1 , 4 , Michel Joyeux1 , 4 , Rachid Soulimani1 , 4 , Jacques Fleurentin1 , 4 , Michèle Sayag3 , François Mortier2 , 4 , Chafique Younos1 , 4 , Jean-Marie Pelt1 , 4
  • 1Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Université de Metz, 1 rue des Récollets, F-57OOO Metz, France
  • 2Laboratoire de Pharmacognosie, Université de Nancy, 5 rue Albert Lebrun, F-54000 Nancy, France
  • 3Laboratoires Biophyland, 34 rue St Romain, F-69008 Lyon, France
  • 4Société Française d'Ethnopharmacologie, Cloître des Récollets, F-57000 Metz, France
Further Information

Publication History


Publication Date:
05 January 2007 (online)


Dried hydro-alcoholic extract of Peumus boldus (Monimiaceae) has been evaluated for hepatoprotective, choleretic and anti-inflammatory effects in mice and rats, in order to validate or to invalidate traditional therapeutic indications. This extract exerted a significant hepatoprotection of tert-butyl hydroperoxide-induced hepatotoxicity in isolated rat hepatocytes (in vitro technique) by reducing the lipid peroxidation and the enzymatic leakage of LDH; this in vitro efficacy was reinforced by a significant hepatoprotection on CCl4-induced hepatotoxicity in mice (in vivo technique), the plant extract reducing the enzymatic leakage of ALAT. Boldine, the main alkaloid of P. boldus appears to be implicated in this hepatoprotective activity.

Choleretic effects, often mentioned in traditional indications, have not been confirmed in rats. Finally, significant and dose-dependent anti-inflammatory effects were obtained on an acute inflammatory process (carrageenan-induced edema test in rats). Boldine does not appear to be involved in such properties.