Planta Med 1991; 57(2): 105-109
DOI: 10.1055/s-2006-960042

© Georg Thieme Verlag Stuttgart · New York

Neurotropic Action of the Hydroalcoholic Extract of Melissa officinalis in the Mouse

Rachid Soulimani1 , 5 , Jacques Fleurentin1 , 5 , François Mortier2 , 5 , René Misslin3 , 5 , Guy Derrieu4 , Jean-Marie Pelt1 , 5
  • 1Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Université de Metz, 1 rue des Recollets, F-57000 Metz, France
  • 2Laboratoire de Pharmacognosie, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Nancy I, 5, rue Albert Lebrun, F-54000 Nancy, France
  • 3Laboratoire de Psychophysiologie, Université Louis Pasteur, 7 rue de l'Université, F-67000 Strasborg, France
  • 4Laboratoire Ardeval, 29 rue Cachin, F-94204 Ivry-Sur-Seine Cedex, France
  • 5Société Française d'Ethnopharmacologie, 1 Rue des Recollets, F-57000 Metz, France
Further Information

Publication History


Publication Date:
05 January 2007 (online)


A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (staircase test) and in a familiar environment test (two compartment test). With high doses, a peripheral analgesic activity was obtained by reducing the acetic acid-induced pain (writhing test); moreover, the plant extract induced the sleep in mice after treatment with an infrahypnotic dose of pentobarbital and potentialised the sleep induced by a hypnotic dose of pentobarbital.