Planta Med 1991; 57(2): 102-104
DOI: 10.1055/s-2006-960041

© Georg Thieme Verlag Stuttgart · New York

Hypoglycemic Effect of Swerchirin from the Hexane Fraction of Swertia chirayita

Madhu Bala Bajpai, R. K. Asthana, N. K. Sharma, S. K. Chatterjee, S. K. Mukherjee
  • Central Drug Research Institute, Lucknow 226001, India
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Publication History


Publication Date:
05 January 2007 (online)


A xanthone was isolated from the hexane fraction of the Swertia chirayita plant and identified as 1,8-dihydroxy-3,5-dimethoxyxanthone (swerchirin). It has a very significant blood sugar lowering effect in fasted, fed, glucose loaded, and tolbutamide pretreated albino rat models. The ED50 for 40% blood sugar lowering in CF male albino rats (body weight 140-165 g) is 23.1 mg/kg/oral. The possibility of its application in clinical therapy for diabetes mellitus needs exploration.