Isogravacridonchlorine: A Potent and Direct Acting Frameshift Mutagen from the Roots of Ruta graveolens

Hubert Paulini; Richard Popp; Oskar Schimmer; Otto Ratka; Erhard Röder

doi:10.1055/s-2006-960019

Planta Medica, Table of Contents

Planta Med 1991; 57(1): 59-61
DOI: 10.1055/s-2006-960019

Papers

Isogravacridonchlorine: A Potent and Direct Acting Frameshift Mutagen from the Roots of Ruta graveolens

Hubert Paulini¹ , Richard Popp¹ , Oskar Schimmer¹ , Otto Ratka² , Erhard Röder³

¹Institut für Botanik und Pharmazeutische Biologie der Universität Erlangen - Nürnberg, Staudtstr.5, D-8520 Erlangen, Federal Republic of Germany
²Fa. Martin Bauer, Dutendorfer Str.5 - 7, D-8531 Vestenbergsgreuth, Federal Republic of Germany
³Pharmazeutisches Institut der Universität, An der Immenburg 4, D-5300 Bonn-Endenich, Federal Republic of Germany

Abstract

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Abstract

The furanoacridone alkaloid isogravacridonchlorine has been isolated from the roots of Ruta graveolens, the structure was elucidated by spectroscopic means. Its mutagenic activity and mode of action was characterized without as well as with metabolic activation using different Salmonella typhimurium strains.

Key words

Ruta graveolens - furanoacridone alkaloid - isogravacridonchlorine - frameshift mutagen - mutagenic response - Salmonella typhimurium

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