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Planta Med 1991; 57(1): 43-46
DOI: 10.1055/s-2006-960014
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© Georg Thieme Verlag Stuttgart · New York

Effects of Constituents of Beli (Aegle marmelos) on Spontaneous Beating and Calcium-Paradox of Myocardial Cells1

Nobuko Kakiuchi2 , Lakshmi R. E. Senaratne2 , 3 , Sheng-Lun Huang2 , Xiu-Wei Yang2 , Masao Hattori2 , Upali Pilapitiya3 , Tsuneo Namba2
  • 2Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
  • 3Bandaranaike Memorial Ayurvedic Research Institute, Nawinna, Maharagama, Sri Lanka
1 Studies on cardio-active crude drugs, part III. For part II, see: Namba, T., Huang, X., Shu, Y., Huang, S., Hattori, M., Kakiuchi, N., Wang, Q., Xu, G. (1989) Planta Med. 55, 501
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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

Effects of methanolic extract of root bark of Beli (Aegle marmelos Corr.), an Ayurvedic crude drug used for heart diseases, and constituents isolated from the extract on spontaneous beating of cultured mouse myocardial cells were examined. The extract at a concentration of 100 µg/ml inhibited the beating rate by approximately 50%. Among the isolated constituents, aurapten was the most potent inhibitor; the IC50 of aurapten is 0.6 µg/ml, which is comparable with that of verapamil, a calcium antagonist. Addition of aurapten at concentrations higher than 1 µg/ml significantly reduced the ratio of morphologically changed myocardial cells which originated from calcium overload caused by successive treatment with calcium-free and calcium-containing solutions.

Key words

Aegle marmelos - aurapten - calcium-overload prevention

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