Planta Med 1991; 57(1): 29-33
DOI: 10.1055/s-2006-960010

© Georg Thieme Verlag Stuttgart · New York

Choleretic Effect of Picroliv, the Hepatoprotective Principle of Picrorhiza kurroa 1

Binduja Shukla, P. K. S. Visen, G. K. Patnaik, B. N. Dhawan
  • ICMR Centre for Advanced Pharmacological Research on Selected Traditional Remedies, Central Drug Research Institute, Post Box No. 173, Lucknow-226001 (U.P.), India
1 CDRI Communication No. 4583
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Publication History


Publication Date:
05 January 2007 (online)


Picroliv, the hepatoprotective principle of the plant Picrorhiza kurroa, showed a dose-dependent (1.5 - 12 mg/kg × 7) choleretic effect in conscious rats and anaesthetised guinea pigs. It also possessed a marked anticholestatic effect against paracetamol- and ethynylestradiol-induced cholestasis. It antagonised the changes in bile volume as well as the contents (bile salts and bile acids). Silymarin, a known hepatoprotective agent, was tested simultaneously for comparison. Picroliv was found to be a more potent choleretic and anticholestatic agent than silymarin.