© Georg Thieme Verlag Stuttgart · New York
Choleretic Effect of Picroliv, the Hepatoprotective Principle of Picrorhiza kurroa 11 CDRI Communication No. 4583
05 January 2007 (online)
Picroliv, the hepatoprotective principle of the plant Picrorhiza kurroa, showed a dose-dependent (1.5 - 12 mg/kg × 7) choleretic effect in conscious rats and anaesthetised guinea pigs. It also possessed a marked anticholestatic effect against paracetamol- and ethynylestradiol-induced cholestasis. It antagonised the changes in bile volume as well as the contents (bile salts and bile acids). Silymarin, a known hepatoprotective agent, was tested simultaneously for comparison. Picroliv was found to be a more potent choleretic and anticholestatic agent than silymarin.
Picrorhiza kurroa - Picroliv - hepatoprotective agents - choleretic activity - anticholestatic activity - silymarin