Planta Medica, Table of Contents Planta Med 1993; 59(6): 533-536DOI: 10.1055/s-2006-959755 Papers © Georg Thieme Verlag Stuttgart · New YorkAnti-Inflammatory Activity of the Essential Oil of Bupleurum fruticescens S. Martin, E. Padilla, M. A. Ocete, J. Galvez, J. Jiménez, A. Zarzuelo Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, E-18071 Granada, Spain Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Abstract The essential oil of Bupleurum fruticescens was investigated qualitatively and quantitatively by GC and GC-MS analyses. The anti-inflammatory activity of the whole essential oil and its major components was also investigated in the rat hindpaw edema model induced by carrageenin or by PGE1. The anti-inflammatory activity shown by the essential oil can be attributed to the two major components, α-pinene and β-caryophyllene. In order to know the role of the adrenal glands in the anti-inflammatory activity exerted by the two major components of the essential oil, they were studied against the carrageenin-induced hindpaw edema in adrenolectomized rats. It is concluded that α-pinene needs the integrity of the adrenal glands to exert its anti-inflammatory activity, as opposed to β-caryophyllene which was also active in adrenolectomized animals. Key words Bupleurum fruticescens - Umbelliferae - anti-inflammatory activity - α-pinene - β-caryophyllene PDF (321 kb)
