Planta Med 1993; 59(5): 451-454
DOI: 10.1055/s-2006-959730

© Georg Thieme Verlag Stuttgart · New York

Three Non-Phenolic Diarylheptanoids with Anti-Inflammatory Activity from Curcuma xanthorrhiza

P. Claeson1 , A. Panthong2 , P. Tuchinda1 , V. Reutrakul1 , D. Kanjanapothi2 , W. C. Taylor3 , T. Santisuk4
  • 1Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
  • 2Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand
  • 3Department of Organic Chemistry, University of Sydney, N.S.W. 2006, Australia
  • 4The Forest Herbarium, Royal Forestry Department, Bangkok 10900, Thailand
Further Information

Publication History



Publication Date:
04 January 2007 (online)


Bioassay-guided fractionation of a hexane extract of the rhizomes of Curcuma xanthorrhiza Roxb. (Zingiberaceae) led to the isolation of three non-phenolic diarylheptanoids, identified mainly by high-field 1H-NMR as trans-trans-1,7-diphenyl-1,3-heptadien-4-one (alnustone), trans-1,7-diprienyl-1-hepten-5-ol, and trans,trans-1,7-diphenyl-1,3-heptadien-5-ol. The latter is reported for the first time as a plant constituent. Germacrone, curzerenone, and cinnamaldehyde were also isolated and identified. The three diarylheptanoids all exerted significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats.