Abstract
The effect of Calceolarioside A, a phenyl-propanoid glycoside (PhG), isolated from
Calceolaria hypericina, was studied on rabbit platelets in vitro. Calceolarioside A induced a dose-related aggregant effect on rabbit platelets. Indomethacin
did not modify the Calceolarioside A-induced aggregant effect. Furthermore, no modification
was exerted by phenoxy-benzamine, BW 577C, and WEB 2086 on the PhG aggregant effect.
On the contrary, TMB-8, an intracellular calcium blocker, significantly reduced the
PhG effect. The latter result suggests that Calceolarioside A aggregation may be partly
related to a calcium-dependent mechanism.
Key words
Calceolaria hypericina
- Calceolarioside A - phenylpropanoid glycosides - platelet aggregation
