Linoleate-Rich Triacylglycerol in Panax pseudo-ginseng Improves Erythrocyte Deformability in vitro

C. Y. Hong; L. J. Lai; S. F. Yeh

doi:10.1055/s-2006-959691

Planta Medica, Table of Contents

Planta Med 1993; 59(4): 323-325
DOI: 10.1055/s-2006-959691

Papers

Linoleate-Rich Triacylglycerol in Panax pseudo-ginseng Improves Erythrocyte Deformability in vitro

C. Y. Hong¹ ^, ² ^, ⁴ , L. J. Lai⁴ , S. F. Yeh³

¹Institute of Traditional Medicine, National Yang-Ming Medical College, Shih-Pai, Taipei, Taiwan
²Institute of Clinical Medicine, National Yang-Ming Medical College, Shih-Pai, Taipei, Taiwan
³Institute of Biochemistry, National Yang-Ming Medical College, Shih-Pai, Taipei, Taiwan
⁴Department of Medicine, Veterans General Hospital, Taipei, Taiwan

Abstract

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Abstract

With field's filtration technique as a bio-assay for evaluating red blood cell (RBC) deformability, we purified from Panax pseudo-ginseng an active component that improved the deformability of calcium-loaded RBC. NMR and mass spectrometric studies showed that the purified substance was a triacylglycerol (TG) with linoleic acid as the major fatty acid residue in the esterified positions of glycerol. The mechanism for this TG to improve RBC deformability could be a modification of membrane fluidity rather than a competitive antagonism with calcium ion.

Key words

Panax pseudo-ginseng - erythrocyte deformability - triacylglycerol - calcium ion - linoleic acid

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