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Planta Med 1993; 59(3): 246-249
DOI: 10.1055/s-2006-959660
Paper

© Georg Thieme Verlag Stuttgart · New York

Antineoplastic and Antiviral Activities of Some Cyclolignans

A. San Feliciano1 , 3 , M. Gordaliza1 , J. M. Miguel del Corral1 , M. A. Castro1 , M. D. García-Grávalos2 , P. Ruiz-Lázaro2
  • 1Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Salamanca, E-37007 Salamanca, Spain
  • 2PharmaMar S.A. c/Calera 3, Tres Cantos, E-28760 Madrid, Spain
  • 3Address for correspondence
Further Information

Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

Nineteen cyclolignans of varied structures, most of them isolated from Juniperus sabina leaves, were evaluated for their antineoplastic and anti-viral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while the antiviral assays were performed on herpes simplex virus type 1 infecting fibroblasts of monkey kidney (HSV-1/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both types of assays at concentrations below 1 µg/ml; deoxypodophyllotoxin and β-peltatin A methyl ether being the most potent compounds in all cases, with IC50 values in the range 2.5-4 ng/ml for the three neoplastic systems.

Key words

Juniperus sabina - Cupressaceae - cyclolignans - antineoplastic - P-388 - A-549 - HT-29 - antiviral - HSV-1.VSV.

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