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Planta Med 1993; 59(3): 215-217
DOI: 10.1055/s-2006-959654
Paper

© Georg Thieme Verlag Stuttgart · New York

The Gastric Antiulcer Effects of the Leaves of the Neem Tree

G. P. Garg1 , S. K. Nigam2 , C. W. Ogle1 , 3
  • 1Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5, Sassoon Road, Hong Kong
  • 2National Botanical Research Institute, Lucknow, India
  • 3Address for correspondence
Further Information

Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

The antiulcer effect of aqueous extracts of the leaves of the neem tree was investigated in rats exposed to 2-h cold-restraint stress or given ethanol orally for 1 h. Extracts were administered in doses of 10,40, or 160 mg leaf/kg body weight, either as single- or five-dose pretreatment regimens. Neem dose-dependently reduced gastric ulcer severity in rats subjected to stress and also decreased ethanol provoked gastric mucosal damage. The extract appeared to prevent mast cell degranulation and to increase the amount of adherent gastric mucus in stressed animals. These effects may explain, at least in part, the mode of the antiulcer action of neem.

Key words

Neem tree - Melia azadirachta - Azadirachta indica - antiulcer activity.

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