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DOI: 10.1055/s-2006-959651
© Georg Thieme Verlag Stuttgart · New York
Inhibitory Effects of Berberine-Type Alkaloids on Elastase
Publication History
1992
1992
Publication Date:
04 January 2007 (online)
Abstract
Berberine-type alkaloids and some structurally related alkaloids were tested for inhibitory activity on porcine pancreatic elastase (PPE) and human sputum elastase (HSE). The chlorides of berberine, coptisine, and sanguinarine significantly inhibited the elastolytic activity of both the enzymes, but tetrahydroberberine had no effect on the activity. It seems that the quaternary nitrogen of the alkaloids plays an important role in the inhibition of elastolytic activity. Amidolytic activity of the elastases was not affected by any of the alkaloids tested.
Key words
Porcine pancreatic elastase - human sputum elastase - anti-elastolytic activity - anti-amidolytic activity - berberine-type alkaloid - quaternary nitrogen.