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Planta Med 1993; 59(2): 101-105
DOI: 10.1055/s-2006-959622
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© Georg Thieme Verlag Stuttgart · New York

Activity on the Central Nervous System of Himanthalia elongata; Part II*

J. M. Anca, M. Lamela, M. A. Gato, I. Cadavid, J. M. Calleja
  • Departamento de Farmacología, Farmacia y Tecnología Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15706 Santiago de Compostela, Spain
* For Part I, see Ref. (5)
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

We report the effects on the central nervous system (CNS) and on analgesic activity of a fraction (F2) obtained from a Himanthalia elongata extract. The fraction was assayed for effects on spontaneous locomotor activity, d-amphetamine-induced hypermotility, motor coordination, muscular relaxation, rectal temperature, sodium pentobarbital-induced hypnosis, and pentylenetetrazole-induced convulsions. Analgesic activity was evaluated using the hot plate test and the Randall-Selitto test (1). The fraction caused significant reductions in spontaneous locomotor activity, hypermotility, rectal temperature, and motor coordination and postponed pentylenetetrazole-induced death, but no effect was noted on muscle relaxation or the duration of sodium pentobarbital-induced sleep. The fraction exhibited central analgesic effects in the hot plate and Randall-Selitto tests.

Key words

Himanthalia elongata - Phaeoficeae - CNS activity - analgesic activity

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