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Planta Med 1994; 60(5): 391-394
DOI: 10.1055/s-2006-959516
Paper

© Georg Thieme Verlag Stuttgart · New York

Antinociceptive Mechanism of the Actonitine Alkaloids Mesaconitine and Benzoylmesaconine

Yasuyuki Suzuki1 , Tsutomu Oyama1 , Atsushi Ishige2 , Tomoko Isono1 , Akitoshi Asami1 , Yoshiki Ikeda1 , Masamichi Noguchi1 , Yuji Omiya1
  • 1Pain Research Laboratory, Tsumura & Co., Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-11, Japan
  • 2Tsumura Central Research Laboratories, Tsumura & Co., Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-11, Japan
Further Information

Publication History

1993

1994

Publication Date:
04 January 2007 (online)

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Abstract

We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.

Key words

Mesaconitine - benzoylmesaconine - Aconitum carmichaeli - Ranunculaceae - analgesia - brain stem

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